在儿科前糖尿病诊所人口中发展为2型糖尿病的危险因素
Natasha Belsky1, Jaclyn Tamaroff2, Ashley H Shoemaker2
1Vanderbilt University School of Medicine, Nashville, TN 37212, USA.
Journal of the Endocrine Society
|October 16, 2023
概括
儿科糖尿病前期到2型糖尿病 (T2D) 的进展是由初始HbA1c和2小时葡萄糖水平预测的. 像体重管理和甲胺这样的干预措施可能会延迟风险青少年T2D的发展.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 代谢障碍 代谢障碍 代谢障碍
- 糖尿病研究 糖尿病研究
背景情况:
- 儿童2型糖尿病 (T2D) 的患病率不断上升,需要更好地识别有风险的个体.
- 目前对儿科糖尿病前期的定义在预测T2D进展方面缺乏明确性.
- 早期干预策略对于管理面临T2D风险的年轻人至关重要.
研究的目的:
- 确定从儿科糖尿病前期发展到T2D的预测因素.
- 评估各种诊断标准在风险分层中的有用性.
- 探索预防儿童T2D的潜在干预措施.
主要方法:
- 在儿童糖尿病前期诊所7年内对552名患者的回顾性图表审查.
- 纳入标准:血红蛋白A1c (HbA1c) 和口服葡萄糖耐受性测试 (OGTT) 葡萄糖水平.
- 排除标准:1型糖尿病,MODY,或在初次访问时存在的T2D.
主要成果:
- 6.5%的患者在平均2.4年内发展为T2D.
- 进展者最初的BMI,HbA1c,2小时后的葡萄糖和C-水平较高.
- 男性性别,更高的初始HbA1c和更高的2小时葡萄糖是T2D进展的显著预测因素.
结论:
- 最初的HbA1c和2小时的OGTT葡萄糖是儿童糖尿病前期T2D进展的关键预测因素.
- 禁食血葡萄糖在风险分层方面效果较差.
- 体重稳定和甲福林治疗可能有助于预防儿童T2D.
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