病毒后的嗅觉损失和帕洛斯米亚
Zhen Yu Liu1, Luigi Angelo Vaira2, Paolo Boscolo-Rizzo3
1Department of ENT Surgery, Royal Brisbane and Women's Hospital, Herston, QLD, Australia.
BMJ medicine
|October 16, 2023
概括
SARS-CoV-2 感染经常导致嗅觉功能障碍,包括嗅觉丧失和. 了解机制和探索治疗方法,如嗅觉训练,对于患者的康复至关重要.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 神经科学是一个神经科学.
- 传染性疾病 传染性疾病
背景情况:
- SARS-CoV-2 感染是嗅觉功能障碍的主要原因,影响高达 50% 的个人.
- 这种功能障碍包括嗅觉丧失和帕洛斯米亚,这是令人痛苦的嗅觉扭曲,影响生活质量.
- 虽然早期的嗅觉丧失机制已被理解,但在病毒感染后持续的功能障碍和呼吸障碍需要进一步调查.
研究的目的:
- 在病毒后嗅觉功能障碍中将帕洛斯米亚置于背景中.
- 探索潜在的分子机制,潜在的持续的嗅觉功能障碍和parosmia.
- 审查嗅觉功能障碍的当前和潜在的治疗选择.
主要方法:
- 文献综述和对SARS-CoV-2和嗅觉功能障碍现有研究的综合.
- 分析拟议的分子机制,包括细胞变化和受体表达.
- 评估当前的治疗策略和研究缺口.
主要成果:
- 嗅觉功能障碍,特别是,是SARS-CoV-2感染的重要和令人痛苦的后果.
- 持续的嗅觉功能障碍的潜在机制包括神经元枯竭,炎症和受体表达的改变.
- 有效的治疗选择有限,嗅觉培训和支持性护理至关重要.
结论:
- 需要进一步的研究来阐明持续的嗅觉功能障碍和的确切机制.
- 目前,支持类固醇或补充剂等治疗方法的证据不足,以恢复嗅觉.
- 研究各种干预措施对定量嗅觉功能和帕洛斯米亚的有效性至关重要.
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