在患有原发性副甲状腺症的患者中,自身免疫性风湿性疾病的患病率增加
1Department of Endocrinology, Metabolism and Diabetes, Health Sciences University, Bursa State Hospital, Bursa, TUR.
Cureus
|October 16, 2023
概括
自免疫性类风湿病 (ARDs) 在原发性偏甲状腺症 (PHPT) 患者中更为常见. 在ARD之后,PHPT通常会发展,这表明ARD可能会引发轻度的PHPT,特别是在长时间的疾病持续时间和略高的情况下.
科学领域:
- 骨质免疫学 骨质免疫学
- 内分泌学 在内分泌学.
- 类风湿病学 类风湿病学
背景情况:
- 副甲状腺激素 (PTH) 和与迪克科夫相关的蛋白1 (DKK-1) 涉及自身免疫性风湿性疾病 (ARD) 和骨免疫学.
- 关于原发性偏甲状腺症 (PHPT) 和ARDs之间的关联存在有限的研究.
研究的目的:
- 调查PHPT患者中ARDs的患病率.
- 探索PHPT和ARDs之间的时间关系和相关性.
主要方法:
- 这是一项回顾性研究,比较了225名PHPT患者和386名对照人群 (甲状腺结节).
- 对电子医院记录进行选,以查找至少三个月前诊断的ARD.
- 纳入标准:完整的血清学测试和正在进行的类风湿病随访.
主要成果:
- 在PHPT患者中,ARD的患病率明显高于对照组 (1.04%,p < 0.001).
- 在PHPT中常见的ARD:类风湿性关节炎 (4.4%),性脊柱炎 (3.1%),全身性红斑狼 (0.88%),贝赫特病 (0.88%) 和混合结缔组织疾病 (0.44%).
- 在95.45%的ARD病例中,诊断先于PHPT,平均时间为36个月.
- PHPT持续时间与ARD之间的正相关性 (OR = 1.06) 和ARD与水平之间的负相关性 (OR = 0.26).
结论:
- 在PHPT患者中,ARD的患病率较高.
- 与ARD相关的PHPT通常发生在风湿病后,这表明存在潜在的因果关系.
- 长时间的PHPT持续时间和轻微升高的水平是PHPT的ARD的特征,可能源于由ARD引发的副甲状腺激增.
关键词:
结性脊柱炎是一种疾病.自免疫性类风湿性疾病 自免疫性类风湿性疾病贝塞特病是贝塞特的疾病.头与头相关的蛋白1一个副荷尔蒙激素.原发性副甲状腺功能障碍症.类风湿性关节炎 类风湿性关节炎系统性红血性狼 (Systemic Lupus Erythematosus) 是一种全身性狼.更多相关视频
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