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慢性酒精暴露在行动过程中差异性地改变了条状细胞群体的活性

Emily T Baltz¹, Rafael Renteria², Christina M Gremel^1,2

¹The Neurosciences Graduate Program, University of California San Diego, La Jolla, CA 92093, USA.

Addiction neuroscience

|October 16, 2023

概括

长期接触酒精会改变控制行为的大脑电路. 这项研究揭示了背部中间条状体活动的特定变化,这可能解释了酒精使用障碍 (AUD) 中目标导向控制受损的原因.

科学领域:

神经科学是一个神经科学.
成的神经生物学成的神经生物学
行为神经科学行为神经科学

背景情况:

酒精使用障碍 (AUD) 导致持久的执行功能缺陷.
慢性酒精会破坏皮质和条状回路,这对于目标导向行为至关重要.
之前的研究表明,AUD.中脊椎中条体 (DMS) 功能发生变化.

研究的目的:

研究慢性酒精暴露如何影响特定DMS群体在行为过程中的活性.
为了确定是否发现的DMS变化与受损的动作控制相关.

主要方法:

利用纤维光度测量基因识别的DMS群体中的活性 (直接途径,间接途径,快速升的内部神经元).
在之前长期暴露于酒精的动物中,在与行动相关的行为期间检查了活动调制.

主要成果:

之前的慢性酒精暴露增加了在行为过程中DMS直接途径中的活性调节.
相反,酒精暴露降低了DMS间接途径中的活性调节和在动作事件周围快速升的内部神经元.

结论:

结果表明,在长期暴露于酒精后,条状电路活动存在显著的不平衡.
这种被破坏的条纹活动可能是与AUD相关的先前报告的目标导向控制缺陷的基础.

关键词:

酒精饮料酒精饮料酒精饮料酒精饮料决策方式决策方式直接的路径直接的路径背部的中间条纹体.间接的路径间接的路径.

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