在 Opisthorchis viverrini 感染期间,胆道粘膜中的炎症细胞反应:对宿主之间的敏感性差异的洞察
Theerayut Thongrin1, Watcharapol Suyapoh2, WoroDanur Wendo1
1Faculty of Veterinary Medicine, Khon Kaen University, Khon Kaen, Thailand.
Open veterinary journal
|October 16, 2023
概括
宿主易感性影响寄生虫的相互作用. 这项研究比较了受感染Opisthorchis viverrini的易受感染的子和不易受感染的小鼠的炎症反应,揭示了细胞反应中明显的时间模式.
科学领域:
- 寄生虫学的寄生虫学
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
背景情况:
- 主体易感性是主体寄生虫相互作用的关键因素.
- 动物模型对于研究宿主-寄生虫动态至关重要,因为人类研究的局限性.
研究的目的:
- 为了比较敏感的 () 和不敏感的 (小鼠) 模型的胆道中的炎症细胞模式.
- 调查炎症反应和在早期胆管癌发育中的增殖性病变之间的关联.
主要方法:
- 使用叙利亚金色仓鼠 (易感) 和BALB/c小鼠 (不易感) 的比较研究.
- 感染Opisthorchis viverrini metacercariae,然后在多个时间点进行基因病理学和免疫组织化学分析.
- 使用Kruskal-Wallis,Mann-Whitney和Spearman等级测试进行统计分析.
主要成果:
- 小鼠对O. viverrini感染表现出较早的细胞反应,在7-14天达到峰值,并在28日下降.
- 仓鼠表现出延迟但持续的炎症反应,在28日达到峰值,并保持高水平到56日.
- 在感染后的多个时间点,在小鼠和仓鼠之间观察到炎症细胞数量的显著差异.
结论:
- 非敏感模型 (老鼠) 显示较早的,短暂的炎症反应,而敏感模型 (仓鼠) 显示较晚的,持续的对O. viverrini.反应.
- 这两种动物都可作为研究受 opisthorchiasis 易感性及其病理后果的有价值的模型.
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