多囊卵巢综合征中的生物标志物
Alexandra M Huffman1,2,3,4, Samar Rezq1,2,3,4,5, Jelina Basnet1,2,3,4
1Department of Cell and Molecular Biology, Jackson, Mississippi, USA, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Current opinion in physiology
|October 16, 2023
概括
多囊卵巢综合征 (PCOS) 是一种常见的内分泌疾病,需要新的生物标志物来对其生殖和代谢并发症进行分析. 本综述探讨了PCOS当前和潜在的生物标志物,帮助研究和临床实践.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 代谢障碍 代谢障碍 代谢障碍
- 生物标志物发现发现
背景情况:
- 多囊卵巢综合征 (PCOS) 是影响生殖年龄女性最普遍的内分泌疾病.
- 结核性卵巢综合症的诊断依赖于高雄性质,性卵巢/ amenorrhea 和/或多囊性卵巢形态.
- 结核复合症与显著的生殖和非生殖健康问题有关,包括肥胖,胰岛素耐药性,糖尿病,脂质失调和高血压.
研究的目的:
- 审查多囊卵巢综合征 (PCOS) 的现有和新兴生物标志物.
- 涵盖与PCOS生殖和非生殖方面相关的生物标志物.
- 突出最近的进展,并鼓励进一步研究PCOS生物标志物开发.
主要方法:
- 文献综述侧重于PCOS生物标志物.
- 包括各种生物标记物类别:人体,临床,激素,代谢,炎症,氧化应激和遗传 (非编码RNA).
- 对PCOS的诊断和预后指标进行当前研究的综合.
主要成果:
- PCOS与各种各样的并发症有关,需要全面的生物标志物策略.
- 生物标志物研究的关键领域包括胰岛素/IGF-1系统,脂质,AMH,淋巴激素,类固醇,炎症,氧化应激和非编码RNA.
- 目前没有单一的生物标志物能够捕捉到PCOS的全谱,因此需要采用多方面的方法.
结论:
- 需要验证的生物标志物来管理PCOS的各种临床表现.
- 对新型生物标志物的持续研究对于改善PCOS的诊断,治疗和理解至关重要.
- 本综述概述了目前PCOS生物标志物研究的现状和未来方向.
相关概念视频
02:07Oogenesis
63.8K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.8K
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
99
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
99
01:27Ovarian Cycle
1.3K
The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle...
1.3K