更高的高流动性群体的Box-1水平与缺血性中风患者的白质病变有关
Jie Zhao1, Fang Xu2, Wanying Xu1
1Department of Geriatrics, Suzhou Ninth People's Hospital, Soochow University, Suzhou, Jiangsu, 215200, People's Republic of China.
Journal of inflammation research
|October 16, 2023
概括
高流动性组盒子-1 (HMGB1) 水平的升高与中风患者白质病变严重程度的增加相关,特别是在周周结节区域.
科学领域:
- 神经学 神经学
- 生物标志物 生物标志物
- 脑卒中研究 脑卒中研究
背景情况:
- 高流动性组盒-1 (HMGB1) 被认为是疾病严重程度和预后的生物标志物.
- 了解HMGB1在中风病理生理学中的作用对于患者管理至关重要.
研究的目的:
- 调查循环高流动性组盒-1 (HMGB1) 度与急性缺血性中风患者白质病变 (WMLs) 的负担之间的关联.
- 为了确定HMGB1水平是否可以预测WML的严重程度.
主要方法:
- 预计将在2022年6月至12月期间招募287名急性缺血性中风患者.
- 在入院时使用酶相关免疫吸收剂测定测量血清HMGB1水平.
- 使用Fazekas尺度评估WML的严重程度,根据周周结膜和深层WML对患者进行分类.
主要成果:
- 在调整混因子 (OR,4.101;P=0.001) 后,高HMGB1水平与中度至严重的WML显著相关 (Fazekas得分为3-6).
- 在较高的HMGB1水平和中度至严重的周周结膜WML之间观察到更强烈的关联 (Fazekas得分为2-3) (OR,9.181;P = 0.001).
- 当将HMGB1分析为连续变量时,这些关联仍然显著.
结论:
- 血清HMGB1水平升高与中风患者白质病变负担增加有关.
- 这种关联在周周结膜白质病变中尤为明显,这表明HMGB1在这个区域的特殊作用.
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