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预测的促炎性hs-CRP评分和非酒精性脂肪肝疾病

Akinkunmi Paul Okekunle^1,2, Jiyoung Youn¹, Sihan Song¹

¹Department of Food and Nutrition, College of Human Ecology, Seoul National University, Seoul, Korea.

Gastroenterology report

|October 16, 2023

概括

预测较高的亲炎性高敏感性C反应蛋白 (hs-CRP) 评分与非酒精性脂肪性肝病 (NAFLD) 的几率增加有关. 生活方式和饮食调整促进较低的炎症可能有助于预防NAFLD.

科学领域:

肝病学肝病学是一种肝病学.
预防医学预防医学
生物标志物生物标志物

背景情况:

非酒精性脂肪肝 (NAFLD) 是一个重要的全球健康问题.
关于饮食和生活方式对NAFLD发展的影响的研究有限.
炎症在NAFLD的发病过程中起着重要作用.

研究的目的:

调查预测的促炎高灵敏性C反应蛋白 (hs-CRP) 评分与NAFLD流行率之间的关联.
探索由各种风险因素衍生的复合hs-CRP得分的预测值.

主要方法:

分析了1076名韩国成年人的队列,2011年至2021年数据更新.
通过肝脏超声波证实了NAFLD的诊断.
使用后勤回归模型计算NAFLD的概率比率 (OR) 和95%置信区间 (CI) 在预测的亲炎性hs-CRP得分的三位数中.

主要成果:

在综合和性别特定分析中,观察到较高预测的益炎性hs-CRP得分和较高的NAFLD几率之间存在显著的积极关联.
对于男女组合,NAFLD的OR从1.00增加到18.25在hs-CRP得分线上.
亚组分析显示,男性 (ORs高达3.26) 和女性 (ORs高达16.71) 的NAFLD几率大幅增加,hs-CRP得分更高.

结论:

预测的亲炎性hs-CRP得分是NAFLD患病率的重要预测指标.
实施生活方式和饮食修改以减少炎症可能是预防NAFLD的关键策略.

关键词:

脂肪肝是一种脂肪肝.高灵敏度的C反应性蛋白质非酒精性脂肪性肝病是非酒精性脂肪性肝病.有助于炎症的促炎症.

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