益生菌改善老鼠皮肤氧化,弹性和结构性质
Boon-Kiat Lee1, Pei Xu1,2, Uma-Mageswary Mageswaran1
1Bioprocess Technology Division, School of Industrial Technology, Universiti Sains Malaysia, Penang 800, Malaysia.
Preventive nutrition and food science
|October 16, 2023
概括
利莫西拉克托巴西勒斯发酵USM 4189 (LF 4189) 显示出抗氧化特性,可能防止皮肤衰老. 这种益生菌改善了皮肤弹性,并防止了老鼠模型中的细胞衰老.
科学领域:
- 生物遗传学 生物遗传学
- 微生物学 微生物学
- 皮肤病学 皮肤病学
背景情况:
- 皮肤衰老是一种与氧化应激相关的自然过程.
- 益生菌通过反应性代谢物生产具有抗氧化能力.
- 在研究其抗衰老潜力方面,正在研究Limosilactobacillus fermentum USM 4189 (LF 4189).
研究的目的:
- 评估LF 4189在D-银糖诱导衰老老鼠模型中的抗氧化作用.
- 为了确定LF 4189是否可以预防或减轻皮肤衰老标志物.
- 评估LF 4189对氧化应激和细胞衰老的影响.
主要方法:
- 使用D-银河糖诱导衰老的老鼠模型.
- 给老老鼠使用的 Limosilactobacillus fermentum USM 4189 (LF 4189) 药物.
- 测量了血抗氧化活性,脂质过氧化,皮肤弹性,端粒长度,亡和抗氧化酶基因表达.
主要成果:
- 服用LF 4189增加了血抗氧化活性和皮肤弹性 (P<0.05).
- 在老老鼠中,LF 4189阻止了端粒缩短和降低了apoptotic活动.
- LF 4189降低了关键抗氧化酶基因的表达,表明减少了自由基清除需求.
结论:
- 利莫西拉克托巴西勒斯发酵USM 4189 (LF 4189) 具有显著的抗氧化特性.
- LF 4189显示出作为一种改善皮肤健康的抗衰老干预措施的潜力.
- 像LF 4189这样的益生菌可能提供一种饮食方法来对抗皮肤衰老和氧化应激.
更多相关视频
04:30Quantifying the Modulation of Elastase Enzyme Activity Through Colorimetric Analysis
Published on: January 17, 2025
1.1K
10:05Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ
Published on: May 8, 2020
2.0K
相关概念视频
01:19The Effect of Aging on Tissues
2.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.1K
01:26Aging
60
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
60