在妊娠糖尿病中,第一季度GPR120水平的预测值
Qingwen He1, Mengyuan Lin2, Zhenhong Wu1
1Department of Public Health, Women's Hospital of Jiangnan University, Wuxi, China.
Frontiers in endocrinology
|October 16, 2023
概括
孕期糖尿病 (GDM) 的早期诊断至关重要. 研究人员发现,更高的G蛋白结合受体120 (GPR120) 水平在怀孕早期可以预测GDM风险,使及时干预和改善结果.
科学领域:
- 产科和妇科 产科和妇科
- 内分泌学 在内分泌学.
- 生物标志物发现发现
背景情况:
- 早期诊断妊娠糖尿病 (GDM) 对于减少不良的孕产妇和产周结局至关重要.
- 目前,没有确立的生物标志物或临床预测模型可用于怀孕早期GDM检测.
- 这项研究解决了早期GDM诊断工具的需求.
研究的目的:
- 在怀孕早期识别血清G蛋白结合受体120 (GPR120) 水平.
- 使用早期怀孕指标开发GDM的预测模型.
- 为早期GDM风险评估建立可靠的方法.
主要方法:
- 进行了一项前性队列研究,涉及250名孕妇 (125名患有GDM).
- 在白细胞中使用定量PCR量化GPR120表达.
- 最小绝对收缩和选择运算符 (LASSO) 和多变量后勤回归被用来构建一个预测性名ogram模型.
主要成果:
- 与正常组相比,患有GDM的孕妇在第一季度的GPR120表达显着更高 (p <0.05).
- 开发的诺米图,包括GPR120,禁食血葡萄糖,胆固醇和脂蛋白,显示出高预测准确度 (AUC在训练中为0.996,在验证中为0.992).
- 命名图表显示出优异的校准,区分和临床适用性,通过决策曲线分析验证.
结论:
- 第一个三个月的高GPR120表达是预测GDM发病的潜在生物标志物.
- 在怀孕早期整合GPR120水平的诺莫грам为GDM提供了强大的预测能力.
- 这种预测模型可以帮助早期发现和管理GDM.
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