益生菌 Lactobacillus 和传播抗生素耐药性的潜在风险:系统性审查
Ali Shahali1,2, Rasool Soltani3, Vajihe Akbari1
1Department of Pharmaceutical Biotechnology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.
Research in pharmaceutical sciences
|October 16, 2023
概括
益生菌 Lactobacillus 菌株可以携带抗生素耐药性基因. 这些基因,如tet和erm,可以转移到其他细菌,增加抗生素耐药性传播的风险,特别是在脆弱人群中.
科学领域:
- 微生物学 微生物学
- 遗传学 是一个遗传学.
- 公共卫生 公共卫生
背景情况:
- 益生菌 Lactobacillus 菌株在食品补充剂中广泛使用.
- 这些细菌越来越多地被认为是抗生素耐药性基因的潜在储存库.
- 了解这种耐药性的特征对于公共卫生至关重要.
研究的目的:
- 审查和讨论Lactobacillus益生菌中抗生素耐药性的表型和基因型特征.
- 评估抗生素耐药性基因从Lactobacillus转移到其他细菌的可能性.
主要方法:
- 在主要的科学数据库 (谷歌学者,PubMed,科学网,Scopus) 进行了全面的文献搜索,截至2022年2月.
- 纳入标准集中在检查Lactobacillus益生菌中抗生素耐药性的研究和对来自Lactobacillus的抗生素耐药基因转移的调查上.
主要成果:
- 乳酸菌益生菌通常表现出对蛋白质合成抑制剂 (87.5%) 和细胞壁合成抑制剂 (62.5%) 的耐药性.
- 在九项研究中报告了从乳杆菌到致病细菌的抗生素耐药性基因转移,主要使用体外方法.
- 特定的耐药基因,如TET和ERM,被认为是可转移的.
结论:
- 抗生素耐药性基因从Lactobacillus益生菌的可转移性对抗生素耐药性的传播构成重大风险.
- 为了评估这些特征的潜在传播,特别是新生儿和老年人等高风险群体,需要进行进一步的研究.
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