模式识别受体在感知 Mycobacterium 结核病中的作用
S M Neamul Kabir Zihad1, Nazifa Sifat2, Mohammad Ashraful Islam3
1Department of Pharmacy, State University of Bangladesh, Dhaka, 1205, Bangladesh.
Heliyon
|October 16, 2023
概括
主体免疫细胞使用模式识别受体 (PRR) 来检测Mycobacterium结核病 (Mtb) 连接体,影响结核病的进展. 了解这些相互作用揭示了新药和新疗法的潜在目标.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 病原体与宿主之间的相互作用
背景情况:
- 结核菌 (Mycobacterium tuberculosis,Mtb) 是传染病死亡的主要原因,主要影响宿主免疫细胞.
- 主体免疫细胞对于控制Mtb感染至关重要,但也作为其复制利基.
- Mtb与宿主免疫细胞之间的复杂相互作用决定了结核病的发病过程.
研究的目的:
- 审查宿主模式识别受体 (PRR) 在Mtb识别中的作用.
- 阐明 Mtb 配体-PRR 相互作用和下游信号的分子机制.
- 确定新药和辅助剂开发的潜在治疗点.
主要方法:
- 关于mtb宿主免疫细胞相互作用的科学文献的综述.
- 对PRR家族及其相关的Mtb配体的分析.
- 检查PRR参与启动的信号通路.
- 由 Mtb 识别产生的效应器函数的概述.
主要成果:
- 主体免疫细胞,特别是髓质细胞,利用多种PRR来识别各种Mtb组件 (连接体).
- 特定的Mtb配体参与不同的PRR,触发复杂的信号级联.
- 这些相互作用调节免疫反应,影响宿主防御和Mtb毒性.
- 已经确定了关键适配器分子和下游信号通路.
结论:
- 通过PRR介导的Mtb的识别是结核病原体的核心.
- 对联体-PRR相互作用和信号通路的详细分子洞察力至关重要.
- 这些知识有助于识别用于结核病治疗和预防的新型药物标.
相关概念视频
01:31Defense Against Bacterial Pathogens
1.4K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.4K
01:28Pulmonary Tuberculosis II
244
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
244
01:26Pulmonary Tuberculosis IV
146
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
146
01:31Antigen Processing Pathways
1.0K
MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
MHC Class I: Presenting Endogenous...
MHC Class I: Presenting Endogenous...
1.0K
01:30Bacterial Phylum Actinobacteria
20
Coryneform bacteria are gram-positive, aerobic, nonmotile rods that exhibit irregular, club-shaped, or V-shaped arrangements. Their V-shape results from snapping division, where the inner cell wall layer forms the cross-wall, while the outer layer remains intact until it ruptures on one side, causing the daughter cells to bend away.The primary genera are Corynebacterium and Arthrobacter. Corynebacterium includes diverse species, ranging from saprophytes to pathogens like Corynebacterium...
20
01:31Pulmonary Tuberculosis III
343
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
343