使用纳米材料进行基于葡萄糖氧化酶的协同癌症治疗的级联策略
Ruixuan He1, Peida Yang1, Aoxue Liu1
1School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070, People's Republic of China. lvb@whut.edu.cn.
Journal of materials chemistry. B
|October 16, 2023
概括
葡萄糖氧化酶 (GOx) 饥饿疗法通过向瘤代谢来提供一种新的癌症治疗方法. 本综述探讨了利用GOx进行增强协同作用的癌症治疗的创新纳米平台策略.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
- 癌症治疗方法 癌症治疗方法
背景情况:
- 基于纳米材料的癌症疗法受到瘤微环境 (TME) 的阻碍.
- 使用葡萄糖氧化酶 (GOx) 的饥饿疗法针对瘤细胞代谢.
- 基于GOx的策略可以修改TME的特性,如酸度,H2O2水平和缺氧.
研究的目的:
- 通过纳米平台审查基于GOx的协同作用的癌症治疗的创新级联策略.
- 为GOx介导的协同效应方案提供合理纳米平台设计的全面参考.
- 突出GOx在操纵TME进行晚期癌症治疗方面的潜力.
主要方法:
- 关于使用GOx用于协同癌症治疗的纳米平台的综合文献综述.
- 对代表性范式的分析和对基于GOx的级联策略的最新报告.
- 专注于纳米平台设计,利用GOx改变TME特征.
主要成果:
- 基于GOx的纳米平台通过调节TME,使协同作用的癌症治疗成为可能.
- 涉及GOx的级联策略显示出各种治疗应用的巨大潜力.
- 现有的审查缺乏全面阐明用于GOx介导协同疗法的纳米平台设计.
结论:
- 基于GOx的纳米平台为协同癌症治疗提供了一个有前途的途径.
- 对GOx促进疗法的临床转化需要进一步的研究和批判性观点.
- 本综述为基于GOx的协同作用的癌症治疗提供了对合理纳米平台设计的见解.
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