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甲状腺功能障碍与未破裂的内动脉瘤有关吗? 来自韩国的基于人口的,嵌套的病例控制研究.
Hyeree Park1,2,3, Sun Wook Cho4, Sung Ho Lee5
1Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
Thyroid : official journal of the American Thyroid Association
|October 16, 2023
概括
甲状腺功能低下症会增加内动脉瘤的风险,而甲状腺功能障碍症可能会降低风险. 甲状腺激素替代疗法可能会提供对动脉瘤发展的保护.
科学领域:
- 内分泌学 在内分泌学.
- 神经学 神经学
- 流行病学 流行病学
背景情况:
- 内动脉瘤 (IA) 的已知风险因素有限.
- 甲状腺疾病很常见,可能会影响血管健康.
研究的目的:
- 通过使用现实世界的数据,调查甲状腺疾病和内动脉瘤之间的关联.
- 探索甲状腺激素在IA发展中的潜在保护作用.
主要方法:
- 使用全国范围的韩国医疗保险数据 (2002-2019) 进行了嵌套病例控制研究.
- 5,335个未破裂的IA病例与80,025个对照 (1:15比率) 相匹配.
- 多变量条件后勤回归分析了甲状腺疾病史和IA风险之间的关联.
主要成果:
- 甲状腺功能低下症与未破裂的IA风险增加有关 (aOR: 1.46).
- 甲状腺功能障碍与未破裂的IA风险降低有关 (aOR:0.71).
- 长期使用甲状腺激素 (>5年) 的甲状腺功能低下患者显示IA风险降低 (aOR:0.69).
- 关联在女性中是显著的,但在男性中没有.
结论:
- 甲状腺功能低下是未破裂的IA的危险因素;甲状腺功能障碍可能是保护性的.
- 甲状腺激素可能在防止IA发展方面发挥作用.
- 需要进一步的研究来确认因果关系并阐明生物机制.
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