埃克斯基尼:乳酸生产,运动和心理健康之间的交叉话题
Alberto Souza Sá Filho1,2, Silvio Roberto Barsanulfo1, Sara Socorro Faria1
1Graduate Program in Pharmaceutical Sciences (PPGCF), Evangelical University of Goiás UniEVANGÉLICA, Anápolis, Goiás, Brazil.
乳酸盐是肌肉收缩的副产品,充当激素,影响大脑健康和精神健康. 高强度运动会增加乳酸,增强其作为治疗剂和生物标记物的潜力.
科学领域:
- 运动生理学 运动生理学
- 神经科学是一个神经科学.
- 代谢研究的研究.
背景情况:
- 骨肌细胞释放肌肉激素 (exerkines) 进行器官间的沟通.
- 体会影响骨肌肉,脂肪组织和大脑功能,影响健康.
- 乳酸盐,一种糖分分解的副产品,正在成为具有治疗潜力的关键药物.
研究的目的:
- 探索乳酸作为调解运动引起的健康益处的exerkine的作用.
- 研究乳酸对大脑功能和心理健康的影响.
- 突出乳酸作为减少疾病和促进健康的潜在生物标志物.
主要方法:
- 关于exerkines和乳酸的文献综述.
- 分析乳酸的信号通路 (SIRT,PGC1-α) 和来自大脑的神经营养因子 (BDNF) 的诱导.
- 检查运动强度和肌肉纤维类型 (IIb类型) 对乳酸产生的影响.
主要成果:
- 乳酸中介器官之间的通信,特别是影响大脑.
- 乳酸盐可以通过SIRT和PGC1-α通路诱导BDNF的表达.
- 乳酸度依赖强度,并与快速抽的纤维招募有关,增强大脑反应.
结论:
- 乳酸盐是一种有前途的激素,对心理健康有重大影响.
- 高强度运动是利用乳酸的好处的一个关键策略.
- 乳酸盐显示出作为减少疾病和促进整体健康的生物标志物的潜力.
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