对抗精神病剂剂量的第二次国际共识研究 (ICSAD-2)
Matthew Kt McAdam1, Ross J Baldessarini2,3, Andrea L Murphy1,4
1Department of Psychiatry, Dalhousie University, Halifax, NS, Canada.
Journal of psychopharmacology (Oxford, England)
|October 16, 2023
概括
专家共识为抗精神病药物提供临床相当剂量估计和剂量建议,帮助临床实践和精神病治疗研究. 这项研究更新了44种口服,16种长效注射剂和14种短效注射剂配方的建议.
科学领域:
- 心理药理学 心理药理学
- 临床精神病学 临床精神病学
- 药物的剂量 药物的剂量
背景情况:
- 关于临床相当剂量的专家共识支持在临床实践和研究中使用抗精神病药物.
- 抗精神病剂量建议对于有效治疗精神病至关重要.
研究的目的:
- 为新的抗精神病药物提供最新的剂量等价值和建议.
- 建立44种口服,16种长效注射剂 (LAI) 和14种短效注射剂 (SAI) 配方的剂量共识.
主要方法:
- 一个两步的Delphi调查过程,涉及来自24个国家的72名国际专家.
- 建立关于剂量建议 (起始,目标范围,最大) 和精神分裂症治疗等效剂量的共识.
- 使用口服 olanzapine 和肌内haloperidol 作为剂量等价估计的参考药物.
主要成果:
- 在各个调查阶段,共识有所改善,对LAI配方达成的共识最高,其次是口服药物,对SAI配方达成的共识最低.
- 为全面的抗精神病药物清单提供了更新的等价估计和剂量建议.
- 72名专家提供了关于口服,LAI和SAI配方的数据.
结论:
- 专家的共识作为一个有价值的替代品来估计临床剂量等价物,由于固定的剂量试验的稀有性.
- 这些发现支持临床实践,指南制定和涉及抗精神病药物的研究.
- 更新的剂量信息有助于优化精神病的治疗.
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