人口地图集人类胎儿新兴大脑结构连接的分析
Camilo Calixto1,2, Fedel Machado-Rivas2,3, Davood Karimi1,2
1Computational Radiology Laboratory, Department of Radiology, Boston Children's Hospital, Boston, Massachusetts, USA.
Journal of magnetic resonance imaging : JMRI
|October 16, 2023
概括
人类胎儿大脑连接在怀孕23到35周之间迅速发展,显示出全球和本地效率的提高. 这项研究揭示了第二和第三季度网络的显著改进.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 医疗成像医学成像
背景情况:
- 了解人类胎儿大脑发育受到缺乏子宫内成像数据的限制.
- 由于技术和生物学差异,死后和早产婴儿数据不可靠.
研究的目的:
- 为了评估胎儿大脑结构连接性在怀孕后23至35周之间的变化.
- 使用扩散张力成像 (DTI) 的时空地图集来绘制大脑发育的地图.
主要方法:
- 在公开可用的地图集 (怀孕23至35周) 的DTI数据上进行全脑纤维通道学.
- 使用爱丁堡新生儿地图 (ENA33) 将皮质板分成78个区域.
- 计算了连接矩阵并分析了与妊娠年龄 (GA) 相关的全球效率 (GE),局部效率 (LE),小世界性 (SW),节点效率 (NE) 和中间中心性 (BC).
主要成果:
- 在整个妊娠期内,GE (5.83%) 和LE (5.43%) 的每周显著增加.
- 在整个胎儿发育过程中观察到小世界的存在 (SW).
- 在41个节点中发现了增加的NE,在5个节点中发现了BC的变化, GA的进展,在GE或LE中没有显著的半球差异.
结论:
- 显著的网络发展和完善发生在人类胎儿发育的第二和第三个季度.
- 脑网络的全球整合和局部分离的快速增长是其特点.
- 提供了对典型的胎儿大脑成熟途径的关键见解.
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