C-反应蛋白水平与牙周炎和全身性疾病之间的关系
1Graduate School of Dental Hygiene, Yonsei University, Seodaemun-gu, Seoul, South Korea.
Journal of periodontology
|October 16, 2023
概括
牙周炎增加了诸如高血压和糖尿病等全身性疾病的风险,特别是在具有高C反应蛋白 (CRP) 水平的个体中. 保持口腔健康对于降低这些风险至关重要.
科学领域:
- 口腔健康研究研究 口腔健康研究
- 系统性疾病流行病学
- 生物标记分析 生物标记分析
背景情况:
- 牙周炎与全身性疾病风险有关,但C反应性蛋白 (CRP) 水平的影响尚不清楚.
- 调查牙周炎,全身性疾病和高敏感性CRP (hs-CRP) 之间的关联对于公共卫生至关重要.
- 了解这些关系可以为慢性疾病的预防策略提供信息.
研究的目的:
- 根据hs-CRP水平,研究牙周炎和全身性疾病之间的关联.
- 为了确定由hs-CRP分层的牙周炎患者的特定系统性疾病风险.
- 突出口腔卫生在全身炎症的背景下的重要性.
主要方法:
- 利用了来自韩国国家健康和营养检查调查 (2016-2018) 的数据,其中有16489名参与者.
- 将受试者分为hs-CRP低风险和高风险组,在5316名受试者中使用倾向分数匹配 (PSM).
- 使用后勤回归分析来评估hs-CRP,牙周炎和全身性疾病之间的关联.
主要成果:
- 牙周炎与hs-CRP组中高血压,糖尿病和中风的患病率增加显著相关.
- 在高hs-CRP组中,牙周炎将高血压的风险提高2.1倍,糖尿病的风险增加2.4倍.
- 这些发现强调了牙周炎患者的全身性疾病风险增加,牙周炎患者的炎症标志物增加.
结论:
- 牙周炎的存在显著提高了全身疾病的患病率,特别是在hs-CRP水平较高的个体中.
- 这凸显了保持口腔健康在减轻患有全身性疾病的风险方面发挥的关键作用.
- 针对牙周炎的有针对性的干预措施可以减少相关的全身性疾病的负担.
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