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黑色素瘤从皮内神经瘤发展:关于两名患者的报告
Daniela Ledić Drvar1, Jaka Radoš, Ivana Manola
1Daniela Ledic Drvar, MD, PhD, University Hospital Centre Zagreb Department of Dermatology and Venereology School of Medicine University of Zagreb, Zagreb, Croatia; dledic@kbc-zagreb.hr.
Acta dermatovenerologica Croatica : ADC
|October 16, 2023
概括
皮内瘤恶性转化为黑色素瘤是罕见的,特别是在老年人中. 本报告详细介绍了两起此类病例,强调了对所有瘤 (包括皮内瘤) 的临床和皮肤镜评估对于早期检测的重要性.
科学领域:
- 皮肤病学 皮肤病学
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 皮肤黑色素瘤可以从瘤产生,结节和复合瘤比皮肤内瘤更频繁地涉及.
- 皮内内的恶性转变被认为是罕见的,老年人群的统计发生率很低.
研究的目的:
- 在老年患者中呈现两种罕见的黑色素瘤病例,这些病例是从皮内神经发生的.
- 为了强调皮内内的恶性变化的潜力,挑战以前的假设.
主要方法:
- 详细的临床表现和皮肤镜评估的两个病人与可疑的病变相邻的皮内 nevi.
- 切除病变的组织病理学分析,以确认黑色素瘤诊断,并评估其与潜在的皮内神经的关系.
主要成果:
- 两名老年患者被诊断出患有黑色素瘤,与先前存在的皮内瘤 (瘤相关的黑色素瘤) 相结合.
- 组织病理学揭示了与良性皮内神经细胞相邻的表皮和表面皮肤层中的非典型黑色素细胞.
- 这些病例与罕见的黑色素瘤报告一致,这些黑色素瘤从皮肤瘤中发展,在皮肤瘤附近呈现一种表皮成分.
结论:
- 皮内,虽然通常是良性的,但可以经历恶性转变为黑色素瘤.
- 一个高的怀疑指数和对所有皮肤病变 (包括皮内) 的彻底的临床和皮肤镜评估至关重要.
- 在皮内内附近有可疑的平面黑色细胞病变,需要立即切除和组织病理学评估,以便早期检测黑色素瘤.
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