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脏活检的晚期表现:临床表现和实验室发现
Ehab Mohammed1, Issa Al Salmi1, Ahmed Atris1
1Department of Renal Medicine, The Royal Hospital, Muscat, Oman.
概括
活检对于诊断病至关重要,即使在晚期. 早期诊断和干预对于有效管理慢性病 (CKD) 至关重要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内部医学 内部医学
- 病理学 病理学 病理学
背景情况:
- 活检对于诊断病至关重要,但越来越多的患者在没有确诊的情况下达到末期病.
- 了解接受脏活检的患者的临床和实验室概况对于改善诊断率和患者结果至关重要.
研究的目的:
- 分析经过皮肤原生脏活检的患者的人口,临床,实验室和免疫学发现.
- 评估活检时慢性病 (CKD) 的阶段,并强调早期诊断和管理的必要性.
主要方法:
- 对从2006年1月至2017年12月期间接受皮肤内源性脏活检的530名患者的数据进行前性分析.
- 评估人口统计信息,临床表现,实验室结果 (包括血红蛋白,脂质,白蛋白,蛋白尿,血液和免疫标记),以及放射性发现.
主要成果:
- 该研究包括530名患者,平均年龄为33.9岁;42.8%是男性. 胀和临床尿液变化是常见的表现.
- 大多数患者不是糖尿病患者,有高血压,而且肥胖. 关键的实验室发现包括低血红蛋白,高胆固醇和甘油三,低白蛋白,脏蛋白尿和微观血.
- 很大一部分患者 (超过三分之一) 呈现了晚期的CKD (IIIB-V阶段),表明诊断延迟.
结论:
- 尽管有越来越多未诊断的末期病患者,活检仍然是诊断的基石.
- 活检中晚期CKD的高患病率突显出迫切需要提高认识,早期调查,以及更多地利用活检,以便及时和准确地诊断和管理.
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