在危急疾病期间新生儿急性损伤的原因
Mohamad El-Kalioby1, Abdelmoneim Khashana1, Noha Kamel2
1Department of Pediatrics and Suez Canal University, Ismailia, Egypt.
概括
新生儿急性损伤 (AKI) 影响11.9%的重症新生儿. 关键的危险因素包括围产期窒息,呼吸困难,休克和早产,导致死亡率显著上升.
科学领域:
- 儿科 儿科 儿科
- 新生儿科学 新生儿科学
- 腎臟病學 (nephrology) 是一種醫學.
背景情况:
- 新生儿急性损伤 (AKI) 是一个重大问题,有助于增加重症婴儿的发病率和死亡率.
- 早期识别和了解风险因素对于改善新生儿重症监护室 (NICU) 患者的治疗结果至关重要.
研究的目的:
- 评估新生儿进入新生儿重症监护室的AKI患病率.
- 确定导致该脆弱人群中AKI发展的主要风险因素.
- 分析与新生儿AKI相关的结局和死亡率.
主要方法:
- 研究了一组310名进入NICU的新生儿.
- 血清肌素 (SCr) 水平在入院时,48小时后以及出院或死亡之前都被监测.
- 根据已确定的标准,AKI的诊断是48小时内SCr升高或48-72小时后持续高水平.
主要成果:
- 在被研究的新生儿中,AKI的总发病率为11.9%.
- 发现的最常见的危险因素是围产期窒息 (59.5%),呼吸困扰综合征 (48.6%),休克 (43.2%),早产 (40.5%).
- 毒药物也是一个重要的因素 (64.9%),尽管在统计学上与对照组没有差异. 患有AKI的新生儿的死亡率为62.1%,明显高于没有AKI的新生儿.
结论:
- 在新生儿重症监护室内,AKI在患病的新生儿中普遍存在,其中包括围产期窒息,呼吸困难,休克和早产等重要因素.
- AKI与新生儿的死亡率大幅增加有关,特别是那些出生在36周怀孕之前的新生儿.
- 针对这些风险因素的进一步研究和预防策略对于降低新生儿AKI相关的发病率和死亡率至关重要.
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