随机尿蛋白与肌素比率和24小时尿蛋白分泌在孕前的相关性
Shaista Rashid1, Muhammad Tassaduq Khan2, Erum Jahan1
1Karachi Medical and Dental College, Dow University Hospital, Karachi, Pakistan.
概括
随机尿样中的蛋白质与肌氨酸的比率与24小时蛋白质分泌有很强的相关性. 这一发现表明,点滴尿检可以有效地监测患有先兆子的孕妇的蛋白质水平.
科学领域:
- 产科和妇科 产科和妇科
- 腎臟病學 (nephrology) 是一種醫學.
- 临床化学 临床化学
背景情况:
- 孕前是一种严重的妊娠并发症,其特点是高血压和蛋白尿.
- 对蛋白尿的准确评估对于治疗妊娠前至关重要.
- 传统的24小时尿液收集用于蛋白质分泌是繁的,容易出现错误.
研究的目的:
- 为了评估随机尿蛋白与肌氨酸比率 (UPCR) 和24小时尿蛋白分泌在孕前怀孕妇女之间的相关性.
- 确定UPCR是否可以作为对24小时尿液采集的可靠替代方案,以评估该人群中的蛋白尿.
主要方法:
- 一项涉及50名患有妊娠前的孕妇 (怀孕超过20周,高血压和蛋白尿≥2+) 的横截面研究.
- 收集了两个随机尿样 (上午9点和下午2点) 用于UPCR测量.
- 收集的24小时尿液样本用于评估总蛋白质分泌量.
- 用皮尔森相关系数来分析随机UPCR和24小时蛋白质分泌之间的关系.
主要成果:
- 在随机尿蛋白与肌素比率和24小时尿蛋白分泌之间观察到强烈的正相关性 (r = 0.655;P = 0.01).
- 患者的平均年龄为28.58±5.09岁,平均妊娠年龄为32.74±4.44周.
- 随机UPCR的平均值为0.93 ± 0.7 mg/mg,平均24小时蛋白质分泌量为481.08 ± 20.10 mL.
结论:
- 单空排尿尿样中的尿蛋白与肌氨酸的比率是预先怀孕时24小时蛋白质分泌的可靠指标.
- 随机UPCR提供了一种方便且可能更实用的替代方案,用于24小时收集尿液,用于监测孕前的蛋白尿症.
- 这种方法可以简化妊娠前的诊断和监测过程,提高患者的遵守性,减少医疗保健负担.
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