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Updated: Jul 13, 2025

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor
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Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor

Published on: September 13, 2018

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SPTAN1/NUMB轴感知细胞密度,通过Hippo信号传递抑制细胞生长和瘤发生

Dongxue Su1, Yuxi Li1, Weiji Zhang1

  • 1State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University and.

The Journal of clinical investigation
|October 16, 2023
PubMed
概括

高细胞密度通过SPTAN1和NUMB1/2激活Hippo信号,抑制YAP以维持接触抑制. 低密度可以逆转这种情况,激活YAP并促进细胞生长,这对于了解癌症发展至关重要.

关键词:
癌症 癌症 癌症 癌症细胞生物学 细胞生物学肝癌是一种肝癌.在瘤学瘤学.信号传导传导是指信号的传导.

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