一项前性多中心对高威康 (基于中国多草本提取物的剂) 的受控研究,用于高风险HPV感染
1Medical Center of Diagnosis and Treatment for Cervical Diseases, Obstetrics and Gynaecology Hospital, Fudan University, Shanghai, China. suilong@fudan.edu.cn.
一种中国的多草药 (GWK) 在清除高风险的人类乳头瘤病毒 (hrHPV) 感染和相关的宫病变方面证明了安全性和有效性. 与对照组相比,接受GWK治疗的患者的HRHPV清除率显著更高.
科学领域:
- 妇科 妇科医生 妇科
- 病毒学 病毒学
- 药理学 药理学是指药理学的学科.
背景情况:
- 高风险的人类乳头瘤病毒 (hrHPV) 感染是导致宫癌的主要原因.
- 宫低度状内皮病变 (LSILs) 需要有效的管理,以防止进展.
研究的目的:
- 评估基于中国多草本提取物的安全性和抗病毒功效 (GWK).
- 评估GWK对持久性HRHPV感染和HRHPV引起的宫LSILs患者的HRHPV清除的影响.
主要方法:
- 一项随机对照研究招募了患有持续性 hrHPV (A组) 或 hrHPV 引起的宫LSIL (B组) 的患者.
- 干预组 (A1,B1) 接受了GWK,而对照组 (A2,B2) 接受了安慰剂.
- 在干预后3个月和6个月评估HPV状态;并监测副作用.
主要成果:
- 与对照组相比,在6个月内,GWK治疗导致 hrHPV 清除率显著提高 (A1/A2: 80.0% 与 20.4% 相比;B1/B2: 64.4% 与 15.2%,p<0.001).
- A1组的有效治疗率为84%,B1组为68.9%.
- 干预显示出与HPV清除的强烈关联 (持久性HPV的OR=12,LSIL的OR=10.1),轻度局部副作用的发病率低 (11.5%和11.1%).
结论:
- 中国的多草药染料GWK是安全的,耐受性很好.
- 在促进HPV清除持续的hHPV感染和HPV诱导的宫LSILs方面,GWK显示出希望.
更多相关视频
06:28E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy
Published on: August 1, 2019
13:41Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus
Published on: March 8, 2012
相关概念视频
Study Designs in Epidemiology
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Clinical Trials: Overview
Clinical Trials
There are four phases in a clinical trial. A phase one...
Cancer Prevention
Some...
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
