阴性宫癌是另一种类型的宫癌吗?
1Gynaecology and Obstetrics Department, Medical Faculty, Selcuk University, Konya, Turkey. mehmet_kulhan@yahoo.com.
European review for medical and pharmacological sciences
|October 16, 2023
概括
研究了人类乳头瘤病毒 (HPV) 阴性宫癌. 这些癌症虽然罕见,但预后似乎并不比HPV阳性类型更糟.
科学领域:
- 在瘤学瘤学.
- 病毒学 病毒学
- 妇科瘤学 妇科瘤学
背景情况:
- 人类乳头瘤病毒 (HPV) 是子宫癌的主要原因,但子宫癌的一小部分是HPV阴性.
- 造成HPV-DNA阴性的原因以及这些瘤的临床行为仍然不清楚.
- 了解HPV阴性宫癌对于全面的妇科瘤治疗至关重要.
研究的目的:
- 为了研究HPV阴性宫瘤的临床病理学特征.
- 评估HPV阴性宫癌患者的生存结果.
- 为了确定HPV阴性宫癌是否代表具有不同生物行为的独特子组.
主要方法:
- 对97名接受HPV-DNA检测的宫癌患者的回顾性分析.
- 分类为14个HPV-DNA阴性和83个HPV-DNA阳性组.
- 人口,临床病理学数据和生存率 (PFS,OS) 的比较.
主要成果:
- 在较老年人群中诊断出HPV阴性瘤 (p=0.05) 并缺乏P16染色 (p=0.001).
- 在35.7%的HPV阴性瘤中观察到P53染色.
- 虽然HPV阴性组的生存率似乎更差,但这种差异对于无病生存率 (p=0.224) 或总生存率 (p=0.219) 没有统计学意义.
结论:
- 与HPV阳性癌症相比,HPV阴性宫癌的预后并不显著差.
- 这些发现表明,HPV阴性宫癌可能与其他解剖部位的HPV相关瘤的预后模式不同.
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