在接受瘤缩因子α抑制剂治疗的患者中遵守结核病预防的水平:一个横截面研究
1Department of Nursing, Faculty of Health Sciences, Gaziantep University, Gaziantep, Turkey. aytac.sema27@gmail.com.
European review for medical and pharmacological sciences
|October 16, 2023
概括
服用TNF-α抑制剂的患者对结核病预防治疗的适度遵守. 建议定期监测患者的坚持和影响因素,以改善结果.
科学领域:
- 免疫学 免疫学 免疫学
- 传染病流行病学 传染病流行病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 瘤亡因子-α (TNF-α) 抑制剂对于控制自身免疫性疾病至关重要.
- 使用TNF-α抑制剂增加了结核病 (TB) 的风险,需要预防性治疗.
- 患者遵守结核病预防措施对于治疗疗效至关重要.
研究的目的:
- 评估基于TNF-α的结核病预防治疗患者的服药水平.
- 确定影响这种患者群体服药坚持的因素.
主要方法:
- 这项研究涉及从2020年12月到2021年6月的一家结核病诊所的135名患者.
- 通过问卷和药物坚持报告量表 (MARS) 收集数据.
- 马斯的分数在5-25之间,较高的分数表明更好的合规性.
主要成果:
- 在接受异化 (INH) 预防的患者中,近一半 (47.4%) 的患者错过了剂量,主要是由于遗忘 (28.9%).
- 平均MARS得分为15.71±6.18,表明适度的坚持.
- 患有结性脊柱炎的患者占该队列的35.6%.
结论:
- 服用TNF-α抑制剂的患者对INH预防有适度的遵守.
- 建议定期监测患者的遵从性和影响因素.
- 改善结核病坚持的干预措施可能会提高这一群体的结核病预防.
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