人类感染的挥发性病毒
Shane Fitzgerald1, Linda Holland2, Waqar Ahmed3
1SFI Insight Centre for Data Analytics, School of Chemical Sciences, National Centre for Sensor Research, Dublin City University, Dublin, Ireland.
Analytical and bioanalytical chemistry
|October 16, 2023
概括
人类挥发性组分析揭示了感染诱导的代谢转变,提供了非侵入性生物标志物. 通过将微生物和临床研究联系起来,可以通过检测挥发性代谢物来加强感染诊断和监测.
科学领域:
- 微生物学 微生物学
- 生物化学 生物化学
- 分析化学 分析化学
背景情况:
- 人类的挥发体,由身体及其微生物组的挥发性排放组成,在感染后发生显著变化.
- 这些挥发性代谢物可以作为检测感染和相关微生物失调的非侵入性生物标志物.
研究的目的:
- 审查感染如何改变挥发性代谢物生产.
- 检查微生物和临床挥发力学中的分析工作流.
- 突出结合微生物和临床数据的重要性,以了解挥发性特征.
主要方法:
- 对微生物和临床挥发力学现有文献的综述.
- 分析工作流程,将微生物研究与临床研究联系起来.
- 识别导致挥发性特征的代谢物种和途径.
主要成果:
- 感染导致人体挥发细胞组发生显著的变化.
- 挥发力学为非侵入性生物标志物发现提供了一个有前途的途径.
- 综合微生物临床方法对于强大的签名阐明至关重要.
结论:
- 结合微生物和临床挥发力学可以提高感染的诊断和监测.
- 对于开发有针对性的,临床上有用的挥发性工作流程,存在新的机会.
- 进一步的研究可以加快目前的感染检测和管理实践.
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