运动训练和db/db小鼠的血管异质性:区域和持续时间依赖的影响的证据
Nada A Sallam1, Baohua Wang2, Ismail Laher3
1Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt.
Naunyn-Schmiedeberg's archives of pharmacology
|October 16, 2023
概括
运动训练通过增强氧化 (NO) 途径,改善了糖尿病小鼠的血管功能. 然而,它并没有完全逆转所有与糖尿病相关的血管损伤,这表明量身定制的运动是2型糖尿病管理的关键.
科学领域:
- 心血管生理学心血管生理学
- 运动科学 运动科学
- 分子生物学分子生物学
背景情况:
- 2型糖尿病与血管功能障碍和心血管风险增加有关.
- 了解区域动脉适应运动训练对于管理糖尿病并发症至关重要.
研究的目的:
- 研究短期和长期运动训练 (ET) 对糖尿病小鼠弹性和肌肉动脉的影响.
- 将这些适应与心血管风险因素和分子标记物的变化相关联.
主要方法:
- 糖尿病 (db/db) 和对照小鼠接受了4周或8周的中度强度ET.
- 评估了胸前动脉和大腿动脉的血管功能 (血管扩张,收缩).
- 血液和组织样本进行了氧化应激,炎症,脂质和蛋白质表达 (SOD,COX,eNOS,Akt) 的分析.
主要成果:
- 短期ET改善了氧化 (NO) 介导的血管扩张,减少了氧化应激,降低了甘油三.
- 长期的ET降低了体重,改善了胰岛素敏感性,并进一步增强了NO介导的血管扩张.
- ET没有恢复非NO/COX依赖的血管扩张或完全减轻动脉过度收缩性; COX-2暂时上调.
结论:
- 运动训练对糖尿病动脉中NO介导的血管扩张有有益影响,可能是通过全身效应.
- ET并不能完全逆转所有糖尿病引起的血管病理.
- 优化运动方案对于全面的2型糖尿病管理至关重要.
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