通过提霍诺夫无模型解卷在长轴视野中的脑 perfusion 估计 PET/CT 扫描仪探索五种不同的 PET 标记器
Henrik Bo Wiberg Larsson1,2, Ian Law3,4, Thomas L Andersen4
1Functional Imaging Unit, Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital-Rigshospitalet, Valdemar Hansens Vej 13, 2600, Glostrup, Denmark. Henrik.bo.wiberg.larsson@regionh.dk.
European journal of nuclear medicine and molecular imaging
|October 16, 2023
概括
新的全身PET扫描仪可以使用各种标记物对脑输液进行无模型估计. 这种方法绕过了隔间建模,为大脑组织提供了详细的生理洞察.
科学领域:
- 核医学就是核医学.
- 放射化学 放射化学是指辐射化学.
- 神经科学是一个神经科学.
背景情况:
- 具有长轴视野 (LAFOV) 的全身PET扫描仪提供了增强的灵敏度和时间分辨率.
- 高时间分辨率 (≤1秒) 理论上允许对所有标志物进行无模型的 perfusion 估计.
- 标志物动力学理论表明,通过先进的PET技术,可以绕过隔间建模.
研究的目的:
- 为了评估无模型的提霍诺夫概括解卷用于估计大脑输液.
- 通过这种方法评估使用五种不同的PET标记物 ([15O]H2O,[11C]PIB,[18F]FE-PE2I,[18F]FDG,[18F]FET) 的可行性.
- 建立一种使用PET进行大脑血流 (CBF) 估计的一般无模型方法.
主要方法:
- 对25名患者进行了动态LAFOV PET扫描.
- PET图像以高同otropic voxel分辨率 (1.65 mm3) 进行了重建.
- 时间框架包括玻尿酸通过过程中的快速1秒间隔,然后是长时间框架,长达60分钟. 动脉输入函数 (AIF) 由下降的大动脉衍生出来. 提霍诺夫的通用解卷被应用到基于体和区域的 perfusion 计算中. 使用残留脉冲响应函数来估计标记器泄漏和提取分数.
主要成果:
- 大脑血流 (CBF) 在丘脑的范围从37到69毫升的血液/分钟/100毫升的组织.
- Voxelwise CBF 计算得出了生理正常范围内的地图.
- 在丘脑中, [15O]H2O, [18F]FE-PE2I, [11C]PIB, [18F]FDG和 [18F]FET的提取分数分别为0.95,0.78,0.62,0.19和0.03.
结论:
- 拉福 (LAFOV) PET扫描仪可方便进行非侵入性,多标志物脑 perfusion 估计.
- 无模型的提霍诺夫方法提供了残留脉冲响应函数.
- 这种方法可以进行详细的生理评估,包括提取分数,流量常数,分布体积和过渡时间分布,提供对正常和病态脑组织的见解.
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