与dupilumab相关的运河管阻塞
Allan Z Nghiem1, Mahreen Ameen2, Nikolas Koutroumanos2
1Royal Free London NHS Foundation Trust, Pond Street, Belsize Park, London, NW3 2QG, UK. allan.nghiem@doctors.org.uk.
International ophthalmology
|October 16, 2023
概括
杜皮卢马布 (Dupilumab) 是一种治疗亚托邦性皮肤炎的药物,可导致管阻塞. 这一案例系列强调了治疗结果,并表明早期的眼科医生转诊可以预防严重的眼部并发症.
科学领域:
- 眼科医生 眼科 眼科
- 皮肤病学 皮肤病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 杜皮卢马布是治疗严重的亚托皮性皮肤炎的生物疗法.
- 眼部并发症,包括白结膜炎和点性狭窄症,与dupilumab使用有关.
- 眼管阻塞代表了一个重要的,虽然不太常见的眼部副作用.
研究的目的:
- 报告用dupilumab治疗的患者发生眼阻塞的病例.
- 描述这些患者的治疗策略和结果.
- 为了解与杜皮卢马布相关的眼部并发症作出贡献.
主要方法:
- 四名患者的回顾性病例系列.
- 眼膜阻塞的诊断由一个眼膜造形顾问.
- 干预措施的文件,包括鼻灌管,保守的管理,和endonasal dacryocystorhinostomy与支架.
主要成果:
- 在开始使用dupilumab后的3.25至4.75年间发生了管阻塞.
- 在三名患者中,在鼻灌管或内鼻乳囊静止术后,成功地实现了症状缓解.
- 一名患者尽管进行了带支架的内鼻乳囊鼻术,但仍有症状.
结论:
- 运河阻塞是杜皮卢马布治疗的潜在眼部并发症.
- 最佳的治疗策略仍在发展;保守措施和手术干预显示出不同的成功.
- 早期的眼科评估和管理可以减轻风险,并改善dupilumab患者的治疗结果.
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