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Updated: Jul 13, 2025

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在Ewing 2008R1试验中,为标准风险的尤文肉瘤患者提供zoledronic酸补充疗法

Raphael Koch1, Lianne Haveman2, Ruth Ladenstein3

  • 1Institute of Biostatistics and Clinical Research, University of Muenster, Germany.

Clinical cancer research : an official journal of the American Association for Cancer Research
|October 16, 2023
PubMed
概括

在标准风险的尤文肉瘤 (EWS) 患者中,龙酸 (ZOL) 维持治疗没有改善无事件生存 (EFS) 或总生存 (OS). 此外,ZOL还导致脏,神经和胃肠道毒性增加.

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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Endothelins (ETs) are potent vasoactive peptides critical in the human body's various physiological and pathological processes. One of the most promising therapeutic strategies for treating pulmonary arterial hypertension (PAH) involves counteracting the effects of these endothelins using a class of drugs known as endothelin receptor antagonists.
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
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