骨肌肉能量与基于加速度计的性能疲劳性之间的关联:肌肉,运动和衰老的研究
Yujia Susanna Qiao1, Adam J Santanasto1, Paul M Coen2
1Department of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Aging cell
|October 16, 2023
概括
骨肌肉的能量,包括最大的氧化酸化 (max OXPHOS),最大的电子转移系统 (max ETS) 和最大的腺三酸盐生产 (ATPmax),与老年人表现疲劳有关. 较低的肌肉能量与增加的疲劳性相关,表明潜在的治疗点.
科学领域:
- 老年学是一门学科.
- 骨肌肉生理学 骨肌肉生理学
- 细胞能量学 细胞能量学
背景情况:
- 性能疲劳,以日常任务的能量不足为特征,是衰老的一个常见问题,可能导致移动障碍.
- 了解疲劳性背后的细胞机制对于开发延迟与年龄有关的功能衰退的干预措施至关重要.
- 骨肌肉的能量被假定是导致表现疲劳的一个关键因素.
研究的目的:
- 为了研究骨肌肉能量和老年人表现疲劳之间的关联.
- 要确定最大氧化酸化 (max OXPHOS),最大电子转移系统 (max ETS) 和最大腺三酸盐产量 (ATPmax) 的测量是否与疲劳性有关.
主要方法:
- 来自肌肉,移动性和衰老研究的参与者 (N=795,70-94岁) 进行了400米的步行,以使用匹兹堡性能疲劳指数 (PPFI) 评估性能疲劳.
- 肌肉活检被用来通过高分辨率呼吸计测量ex vivo最大OXPHOS和最大ETS.
- 在体内评估ATPmax使用31P磁共振光谱,统计分析对相关共变量进行调整.
主要成果:
- 较低的max OXPHOS,max ETS和ATPmax水平与更高的PPFI得分有显著的关联,表明更大的表现疲劳.
- 每一次最大OXPHOS,最大ETS和ATPmax标准偏差的下降都相当于PPFI得分的显著增加.
- 这些发现强调了骨肌肉能量生产能力下降和老年人疲劳增加之间的明显联系.
结论:
- 骨肌肉能量受损与老年人表现疲劳性增加有关.
- 旨在增强肌肉能量生产的治疗策略可能是一个有希望的方法来缓解疲劳.
- 这些干预措施可能会降低老年人群对移动障碍的易感性.
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