概括
血栓形成显微镜 (TEG) 比常规测试更敏感,用于评估心肺旁路手术后6个月以下的婴儿的凝血. 与年龄较大的儿童相比,较年轻的婴儿表现出更大的凝血变化和更高的输血率.
科学领域:
- 儿科手术 儿科手术
- 血液静止和血栓形成
- 凝血诊断 凝血诊断 凝血诊断
背景情况:
- 婴儿凝血系统在6个月之前是不成熟的,这使评估复杂化.
- 儿科医生面临的挑战是选择适合婴儿手术的测试.
- 这项研究将传统测试与在接受心肺旁路 (CPB) 的婴儿中的TEG进行比较.
研究的目的:
- 为了比较传统凝血试验和TEG的灵敏度.
- 为了评估接受CPB手术的婴儿的凝血功能.
- 为了确定较年轻 (<6个月) 和较年长的婴儿之间凝血反应的差异.
主要方法:
- 将PT,APTT,TT和纤维素与TEG参数进行比较 (R-时间, ɑ-角度,K-时间,MA).
- 分析了CPB前后的值及其变化率.
- 婴儿<6个月 (n=72) 和6个月至12岁 (n=76) 的结果比较.
主要成果:
- 两组都显示PT,APTT,R时间,K时间增加,CPB后Fib, ɑ-Angle,MA减少.
- 年龄较小的婴儿在CPB后的R-时间/K-时间增加和 ɑ-角度/MA减少率显著更高 (p < 0.01).
- 较年轻的婴儿需要显著更多的红细胞,血和冷沉积物的术后输血.
结论:
- 血栓形成显微镜 (TEG) 比常规测试更敏感,用于检测手术后幼儿的凝血变化.
- 传统的凝血试验在CPB后的年龄组之间没有显著差异.
- TEG提供了对儿科CPB患者凝血动态的更全面的评估.
相关概念视频
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