相关实验视频

Updated: Jul 13, 2025

In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein
09:22

In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein

Published on: January 2, 2015

18.4K

β-手:基于形菌株的宏循环交叉β形模仿物

Benjamin H Rajewski1, Kamlesh M Makwana1, Isaac J Angera1

  • 1Department of Chemistry & Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States.

Journal of the American Chemical Society
|October 16, 2023
PubMed
概括

研究人员设计了一种模仿毒性tau蛋白结构的新型β手. 这些分子抑制聚和扩散,为阿尔茨海默病 (AD) 和病治疗提供了新的策略.

更多相关视频

An In Vitro Model for Studying Tau Aggregation Using Lentiviral-mediated Transduction of Human Neurons05:51

An In Vitro Model for Studying Tau Aggregation Using Lentiviral-mediated Transduction of Human Neurons

Published on: May 23, 2019

6.0K
Cell-based Assay to Study Antibody-mediated Tau Clearance by Microglia07:18

Cell-based Assay to Study Antibody-mediated Tau Clearance by Microglia

Published on: November 9, 2018

8.4K

相关概念视频

Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
9.6K