保存宿主谷氨胺载体的选择促进了虫/布赫纳拉的代谢整合
Rebecca P Duncan1, Catriona M H Anderson2, David T Thwaites3
1Department of Biology, University of Miami, Coral Gables, FL 33146.
概括
虫中的谷氨胺转运体ApGLNT1通过选择其祖先的功能,进化了氨基酸代谢的调节作用. 这种机制很可能在食水汁的昆虫中广泛存在,这是由于蛋白质结构的保存和共生体的营养供应.
科学领域:
- 进化生物学 进化生物学
- 交生研究 交生研究
- 代谢生物化学 代谢生物化学
背景情况:
- 细菌共生体对于殖民新环境的生物至关重要,经常提供必需的营养素.
- 代谢的整合,特别是氨基酸生物合成,对于食昆虫及其共生生物来说至关重要.
- 虫/布赫纳拉共生体表现出宿主/内生体的代谢互补性,其中载体ApGLNT1发挥着关键作用.
研究的目的:
- 研究ApGLNT1在氨基酸代谢中的调节作用的进化起源.
- 为了确定GLNT1的调节功能是否在具有和没有内共生生物的昆虫物种中得到保护.
- 了解祖先蛋白在宿主-共生体系统进化中的合作.
主要方法:
- 在各种昆虫物种中,ApGLNT1的功能性特征.
- 正义学寻求在昆虫中识别相关的基因.
- 同一性建模分析GLNT1.1的结构保护.
主要成果:
- ApGLNT1的正义基因在昆虫中表现出保存的功能,这表明GLNT1是古老的,结构稳定的.
- ApGLNT1的共生调节作用源于其祖先的功能.
- 虫中主体阿基尼因生物合成的丧失,再加上内生生物阿基尼因的提供,很可能促进了这种调节作用.
结论:
- 在氨基酸代谢中ApGLNT1的调节作用是祖先蛋白合作的一个例子.
- GLNT1可能代表了一种调节食昆虫氨基酸代谢的通用机制.
- 这项研究强调了将祖先蛋白质整合到新的共生环境中的进化重要性.
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