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Updated: Jul 13, 2025

Cycloheximide Chase Analysis of Protein Degradation in Saccharomyces cerevisiae
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通过CRL2识别C-degron的分子基础APPBP2 ubiquitin合酶

Shidong Zhao1, Diana Olmayev-Yaakobov2, Wenwen Ru1

  • 1Ministry of Education Key Laboratory for Cellular Dynamics, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, Peoples Republic of China.

Proceedings of the National Academy of Sciences of the United States of America
|October 16, 2023
PubMed
概括

这项研究揭示了基质受体APPPBP2如何使用低温电子显微镜识别蛋白质降解中的R-x-x-G/C降解子. 它揭示了对蛋白质循环至关重要的双重结合机制.

关键词:
在C-degron下降.化电磁波是一种冷电磁波.库林-RING E3 无素结合酶的使用乌比奎丁-蛋白酶体系统蛋白质降解 蛋白质降解

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