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摄入益生菌是否可以降低孕前的风险? 一个系统的审查

Nayara Valiati¹, Esthela M Puel¹, Cristine M Stefani²

¹Department of Physiological SciencesCenter of Biological Sciences, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil.

Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme

|October 16, 2023

概括

益生菌补充剂可能会略微增加患有并发症的孕妇的孕前风险. 证据非常有限,建议谨慎使用,特别是对于肥胖女性或长期使用.

科学领域:

产科和妇科产科和妇科
微生物学微生物学
公共卫生公共卫生

背景情况:

孕前 (PE) 是怀孕的一个严重并发症.
益生菌在调节PE风险中的作用尚未得到充分证实.
现有的研究尚未综合随机临床试验 (RCT) 的证据.

研究的目的:

系统地审查和分析关于益生菌消费和孕前风险的RCT.
评估益生菌对孕妇前列腺发育的影响.
评估有关益生菌使用和PE的证据的确定性.

主要方法:

在2022年2月之前,对八个数据库,试验注册表和灰色文献进行系统的文献搜索.
包括6项RCT,涉及593名接受益生菌的女性和625名接受安慰剂的女性.
随机效应的元分析使用风险比率 (RR) 和PE的95%置信区间 (CI).

主要成果:

益生菌的消费与PE风险增加12%有关 (RR 1.12,95% CI 0.83-1.53).
没有观察到PE风险的统计显著增加 (p=0.46).
证据的确定性被评为非常低,肥胖妇女的风险可能增加,使用>8周.

结论:

益生菌补充剂可能会略微提高伴随疾病的孕妇的PE率.
目前的证据的确定性非常低,需要谨慎的解释.
需要进一步的高质量的RCT来澄清益生菌在PE预防中的作用.

关键词:

妊娠障碍妊娠障碍妊娠障碍我们的肠道细菌是肠道细菌.乳酸菌种 (lactobacillus) 是一种乳酸菌.我们的微生物群.怀孕怀孕怀孕怀孕怀孕过早出生的早产.

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