在出血老年创伤患者的呈现下降的葡萄糖流量
Tanya Anand1, Anna E Crawford2, Michael Sjoquist3
1Division of Trauma, Critical Care, Burn & Emergency Surgery, Department of Surgery, University of Arizona, Tucson, Arizona. Electronic address: https://twitter.com/tanyaanand8.
The Journal of surgical research
|October 16, 2023
概括
与年轻人 (YA) 相比,受伤的老年人 (OA) 显示了较低的血syndecan-1 (Sdc-1) 水平,这是内皮糖体损伤的标志物. 这表明,在受伤的OA中,调节葡萄糖的流失的机制受损.
科学领域:
- 创伤研究研究创伤研究
- 老年学是一门学科.
- 血管生物学 血管生物学
背景情况:
- 血Syndecan-1 (Sdc-1) 表明内皮葡萄糖体 (EG) 损伤,与不良创伤结果相关.
- 老年人 (OA) 创伤后的EG损伤尚未得到充分理解.
- Sdc-1脱落是EG完整性的一个关键指标.
研究的目的:
- 为了比较Sdc-1在OA创伤患者和年轻成年人的Sdc-1分泌.
- 在OA创伤患者中识别EG sheddases的潜在调节剂.
- 为了研究与年龄相关的EG对重伤害反应的差异.
主要方法:
- 对PROPPR试验数据的二次分析.
- 将重创伤患者分为OA和YA组的分层.
- 血Sdc-1水平的比较和对候选EG调节者的分析.
主要成果:
- 与YA相比,OA在抵达医院后的第3天内具有显著较低的血Sdc-1水平.
- 年龄的增加独立地与Sdc-1水平在抵达时的下降有关.
- 与YA相比,OA中Sdc-1,高流动性组框1和金属蛋白酶-2组织抑制剂的水平较低.
结论:
- 高龄独立地与重创伤患者Sdc-1水平的降低有关.
- 在受伤的OA中,由于抑制的sheddase水平,可能会出现受损的EG裂解调节.
- 这些发现提供了关于OA中血管内皮对创伤的年龄依赖反应的见解.
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