受体放射性核酸疗法在服用长效八类后不久进行
Han Chung Low1, Young Soon Tay1, Simon Yew Kuang Ong
1From the Department of Nuclear Medicine and Molecular Imaging, Singapore General Hospital.
Clinical nuclear medicine
|October 16, 2023
概括
在受体放射性核酸治疗 (PRRT) 之前停止长期作用的八类可能不必要. 一名患有转移性小肠神经内分泌瘤的患者,尽管在接受了八类LAR后不久,但177Lu-DOTATATE的瘤吸收没有减少.
科学领域:
- 在瘤学瘤学.
- 核医学是一种核医学.
- 内分泌学 在内分泌学.
背景情况:
- 神经内分泌瘤 (NETs) 是一组异质的恶性瘤.
- 使用像177 Lu-DOTATATE这样的药物进行受体放射性核酸治疗 (PRRT) 是对转移性NET的成熟治疗方法.
- 索马托斯坦类类似物,如长效重复性 (LAR) 的奥克特雷,通常与PRRT一起或之前使用.
研究的目的:
- 为了评估短时间间隔给予索马托斯塔丁类似物对PRRT疗效的影响.
- 为了研究177 Lu-DOTATATE的瘤吸收,当它在八度胺LAR后不久被施用时.
- 提供关于在PRRT之前扣留索马托他类型的必要性的证据.
主要方法:
- 一个68岁的男性患有转移性sbNET的病例报告.
- 使用177Lu-DOTATATE进行的PRRT的四个周期.
- 在第4周期 (48小时后的octreotide LAR) 与第1-3周期 (4周后的octreotide LAR) 的瘤吸收的比较.
主要成果:
- 第四个循环中177Lu-DOTATATE的瘤吸收并没有减少,尽管在最后一剂octreotide LAR剂量后仅在48小时内给药.
- 这一发现表明,短效索马托斯塔丁类型可能不会显著干扰PRRT疗效.
结论:
- 在进行PRRT之前,必须停止长期起作用的索马托斯塔丁类同类疗法,因此需要重新评估.
- 这一案例支持新出现的证据,即在PRRT之前可能不需要停止服用索马托他丁类比药物.
- 需要进一步的研究来证实这些发现在更大的患者队列中.
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