甲状腺前结构在早期的骨发育中协作起作用,该骨的gnathostome头骨
Jaqueline Isoppo da Cunha1, Alessandra Maria Duarte Barauna1, Ricardo Castilho Garcez2
1Graduate Program of Cell and Developmental Biology, Federal University of Santa Catarina, Florianopolis, SC, Brazil; Stem Cell and Tissue Regeneration Laboratory (LACERT), Federal University of Santa Catarina, Florianopolis, SC, Brazil.
Cells & development
|October 16, 2023
概括
神经细胞形成了头骨中的神经.
科学领域:
- 发育生物学是发展生物学.
- 分子生物学分子生物学
- 遗传学 遗传学是一种遗传学.
背景情况:
- 脊椎动物的头骨发育涉及中皮和神经顶 (NC) 细胞.
- NC细胞有助于骨的前弦域,对神经骨软骨至关重要.
- 形软骨的形成包括前板 (PCP),腹中线 (VM) 脑膜细胞和背部口腔外皮.
研究的目的:
- 调查 gnathostome trabeculae 发育的分子机制.
- 澄清PCP,VM细胞和背部口腔外皮在面发育中的作用.
主要方法:
- 分子信号通路的分析.
- 对基因表达模式的检查 (SHH,SIX3,GLI1,SOX9,NKX2.1) 进行了检查.
主要成果:
- 通过PCP分泌的SHH会在VM细胞中诱导SIX3和GLI1,从而创建一个反循环.
- 由VM衍生的SHH刺激NC细胞的凝聚,以形成状细胞.
- SHH影响NC细胞中的SOX9表达;BMP7和SHH不会影响NKX2.1诱导的状骨形成.
结论:
- PCP,VM细胞和背部口腔外皮之间的分子相互作用对于NC衍生的面发育至关重要.
- SHH信号传递是带软骨形成的关键调节器.
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