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活和草甘混合物的生化和致性作用

Angélica Sabrina Dos Santos Azevedo¹, Josefa Gerlane da Silva², Jéssica Celerino Dos Santos²

¹Programa de Pós-graduação em Saúde e Desenvolvimento Socioambiental - PPGSDS, Universidade de Pernambuco - UPE, Campus Garanhuns, Brazil; Laboratório de Biologia Celular e Molecular, Universidade de Pernambuco - UPE, Campus Garanhuns, Brazil.

Comparative biochemistry and physiology. Toxicology & pharmacology : CBP

|October 16, 2023

概括

杀虫剂混合物,包括pyriproxyfen (PPx) 和草甘 (Gly),在斑马鱼胚胎中显著增加了毒性和致命性. 这项研究表明,即使在低度下,这些常见农业化学品之间也存在协同毒性作用.

科学领域:

环境毒理学环境毒理学
生态毒理学生态毒理学
发展生物学发展生物学

背景情况:

农业化学混合物在害虫防治中很常见,引发了对非目标生物的影响的担忧.
了解像pyriproxyfen (PPx) 和草甘 (Gly) 这样的农药的联合作用对于环境和健康风险评估至关重要.

研究的目的:

为了研究pyriproxyfen和草甘混合物对斑马鱼胚胎发育和生化途径的毒理影响.
为了评估pyriproxyfen和草甘之间的潜在协同作用.

主要方法:

斑马鱼胚胎 (受精后0-72小时) 暴露于不同度的pyriproxyfen,草甘及其混合物.
在基中进行了ADMETox的吸收,分布,新陈代谢,分泌和毒性分析.
使用FET测试评估了原性影响,而通过AChE,SOD和CAT活动以及ROS生成来测量生化影响.

主要成果:

活素+草甘混合物在0.1μg/mL时诱导了50%的致死率,在1μg/mL时诱导了100%的致死率.
发育异常,包括22%缺乏体质形成,在1μg/mL的混合物中观察到.
该混合物增强了毒性作用,包括心率降低,SOD和CAT活性降低,与单个农药相比,超氧化物生成显著增加.

结论:

对pyriproxyfen和草甘的联合暴露在斑马鱼胚胎中表现出协同毒性,导致死亡率增加和发育障碍.
这些发现凸显了在环境风险评估中考虑农药混合物影响的关键需要,因为联合暴露可能比单个化合物更危险.

关键词:

酶活性的酶活性.氧化剂的产生产生氧化剂的产生.协同作用协同作用协同作用甲状腺发育 (teratogenesis) 是一种斑马鱼是一种斑马鱼.

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