对于tFUS的实时声学模拟框架:使用导航系统的可行性研究
Tae Young Park1, Heekyung Koh2, Wonhye Lee3
1Bionics Research Center, Biomedical Research Division, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea; Division of Bio-Medical Science and Technology, KIST School, Korea University of Science and Technology, Seoul 02792, Republic of Korea.
NeuroImage
|October 16, 2023
概括
这项研究引入了一种实时声学模拟系统,用于跨的聚焦超声波 (tFUS) 治疗. 模拟引导导航 (SGN) 系统使用神经网络准确预测声场,改善非侵入性脑部治疗.
科学领域:
- 生物医学工程 生物医学工程
- 医学物理 医学物理
- 神经科学是一个神经科学.
背景情况:
- 穿焦点超声波 (tFUS) 提供非侵入性脑疗法,但由于头骨引起的声学偏差,它面临准确性问题.
- 目前的图像引导导航系统与骨扭曲作斗争,需要进行计算密集的声学模拟.
- 实时声学模拟对于精确的tFUS处理至关重要,但受到高计算成本的阻碍.
研究的目的:
- 开发和验证基于神经网络的框架,用于tFUS的实时声学模拟.
- 实施一个模拟引导导航 (SGN) 系统,将这种实时模拟与现有的导航技术集成在一起.
- 评估拟议的SGN系统用于预测内声场的准确性和速度.
主要方法:
- 用剩余块和多个损失函数的3D条件生成对抗网络 (3D-cGAN) 进行实时声学模拟.
- 3D-cGAN模型是使用传统k-Wave数值声学模拟程序的数据进行训练的.
- 该SGN系统整合了3D-cGAN模拟与标准的图像引导导航.
主要成果:
- 该SGN系统实现了5Hz的实时率 (每次模拟约为0.2秒).
- 数字验证显示平均峰值内压力和焦点位置误差分别为6.8 ± 5.5%和5.3 ± 7.7毫米.
- 使用头骨幻影进行的实验验证,平均误差为4.5%的峰值压力和6.6mm的焦点位置.
结论:
- 拟议的基于神经网络的SGN系统能够准确地实时预测tFUS期间的内声场.
- 这一进步可以显著提高大脑中非侵入性治疗性超声波应用的精度和有效性.
- 该SGN系统证明了tFUS程序实时指导的可行性,克服了传统方法的局限性.
更多相关视频
相关概念视频
Perception of Sound Waves
4.5K
The human ear is not equally sensitive to all frequencies in the audible range. It may perceive sound waves with the same pressure but different frequencies as having different loudness. Moreover, the perception of sound waves depends on the health of an individual's ears, which decays with age. The health of one's ears may also be affected by regular exposure to loud noises.
The pitch of a sound depends on the frequency and the pressure amplitude of the source. Two sounds of the same...
The pitch of a sound depends on the frequency and the pressure amplitude of the source. Two sounds of the same...
4.5K
Perceiving Loudness, Pitch, and Location
220
The human brain perceives pitch through two primary mechanisms reflected in place theory and frequency theory. Each mechanism describes how sound waves are interpreted as specific pitches by the brain, offering insights into the intricate processes of auditory perception.
Place theory, or place coding, suggests that different pitches are heard because various sound waves activate specific locations along the cochlea's basilar membrane. The brain determines the pitch of a sound by...
Place theory, or place coding, suggests that different pitches are heard because various sound waves activate specific locations along the cochlea's basilar membrane. The brain determines the pitch of a sound by...
220
Sound as Pressure Waves
2.4K
Sound waves, which are longitudinal waves, can be modeled as the displacement amplitude varying as a function of the spatial and temporal coordinates. As a column of the medium is displaced, its successive columns are also displaced. As the successive displacements differ relatively, a pressure difference with the surrounding pressure is created. The gauge pressure varies across the medium.
The pressure fluctuation depends on the difference in displacements between the successive points in the...
The pressure fluctuation depends on the difference in displacements between the successive points in the...
2.4K


