体的微观结构组织调解了身体疏忽对精神分裂症社会认知的影响
Emma Corley1, Christina Gleeson1, Emmet Godfrey1
1School of Psychology, University of Galway, Ireland; Center for Neuroimaging Cognition and Genomics, University of Galway, Ireland.
Progress in neuro-psychopharmacology & biological psychiatry
|October 16, 2023
概括
儿童时期的身体疏忽影响了精神分裂症患者的社会认知. 这项研究发现,炎症 (介质素-6) 和大脑中的白质变化调解了这种联系,影响了情绪识别.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 免疫学 免疫学 免疫学
背景情况:
- 早期的生活逆境,特别是身体疏忽,与精神分裂症的发展和社会认知能力受损有关.
- 社会认知缺陷,如情绪识别,是精神分裂症的核心特征.
- 介质素-6 (IL-6) 和体 (CC) 微观结构是潜在的生物通路.
研究的目的:
- 调查IL-6和CC微观结构是否调解了精神分裂症患者童年身体疏忽和社会认知之间的关系.
- 探索涉及IL-6和CC微观结构的顺序调解.
主要方法:
- 评估了58名精神分裂症患者.
- 通过使用CANTAB情感识别任务来测量社会认知.
- 调解分析检查了IL-6和CC分数异构性 (FA) 的作用.
主要成果:
- 体 (CC) 微观结构显著调解了身体疏忽和情绪识别之间的关联.
- 一个连续的调解显示,较高的IL-6和较低的CC FA连续调解了身体疏忽和较差的情感识别之间的联系.
- 在控制共变量时,IL-6调解效应仍然存在,突出显示了它在CC微结构路径中的作用.
结论:
- 精神分裂症中身体忽视和情绪识别受损之间的关联部分是由白质微观结构的改变解释的.
- 炎症过程 (IL-6) 可能起到连续作用,影响CC微观结构,随后影响社会认知.
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