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中心给药的宁诱导了老鼠内沙丁-1神经元中的Fos表达

Shota Saito¹, Hirofumi Hashimoto², Hidefumi Wakashin³

¹Department of Pharmacology, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba-shi, Chiba 260-8670, JAPAN; Department of Rehabilitation, Dokkyo Medical University, 8880 Kitakobayashi, Mibu, Shimotsugagun, Tochigi 321-0293, Japan.

Brain research bulletin

|October 16, 2023

概括

中心给药的素通过激活大脑中的内斯法-1神经元来抑制食物摄入. 这项研究揭示了一种新的食欲调节途径,涉及宁和内沙丁-1 (NUCB2).

科学领域:

神经内分泌学神经内分泌学
调节食欲调节食欲是什么意思
神经信号传递神经信号传递

背景情况:

已知素是一种类激素,当在动物中以中心或外围方式使用时,可减少食物摄入量.
纳斯法-1/NUCB2是一种在中枢神经系统中发现的厌食性神经,通常与其他信号分子共同定位.

研究的目的:

为了研究中央宁给药对大鼠食物和水摄入的影响.
为了检查纳斯法-1-样免疫反活性 (LI) 神经元在施用后的激活.
确定纳斯法-1在调解因诱导的厌食症中的作用.

主要方法:

在老鼠中,Xenin的脑内静脉内给药.
免疫组织化学检测Fos-LI神经元和双免疫组织化学检测Fos和nesfatin-1.
在施用因治疗之前,服用纳斯法-1反感或错感寡核酸.

主要成果:

谢宁的使用增加了多个大脑区域的Fos-LI神经元,包括LC,OVLT,MnPO,SFO,SON,PVN,Arc,LHA,CAN,DR,AP和NTS.
在SON,PVN,Arc,LHA,CAN,DR,AP和NTS中观察到Fos-LI神经元共同表达纳斯法廷-1的显著增加.
纳斯法丁-1反感觉预治疗减轻了因因引起的食抑制,而错觉预治疗没有效果.

结论:

中心给药的宁诱发了厌食症.
素诱导的厌食症与中央纳斯法-1神经元的激活有关.
纳斯法-1在调解色素的厌食效应方面发挥着至关重要的作用.

关键词:

胃口胃口胃口下丘脑的下丘脑是什么意思免疫组织化学免疫组织化学长髓 (Medulla oblongata) 是一个长髓.核聚二烯的核聚二烯是什么?

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