在沙特阿拉伯的B组Streptococcus临床分离物的分子类型和抗菌耐药性
Maha Alzayer1, Manal M Alkhulaifi2, Ahmed Alyami3
1Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia; Department of Microbiology and Immunology, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
Journal of global antimicrobial resistance
|October 16, 2023
概括
沙特阿拉伯的B组链球菌 (GBS) 主要是III和V血清型,对红红和克林达米的高耐药性需要对这种重要的成人病原体进行持续监测.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 乙组链球菌 (GBS) 是严重成人感染的重要原因.
- 沙特阿拉伯GBS的流行病学数据有限.
研究的目的:
- 为了调查沙特阿拉伯GBS的流行病学.
- 描述GBS血清型,毒性因子和成年分离体中的抗菌素耐药性模式.
主要方法:
- 在八个月内从殖民和感染的成年人中收集了GBS分离物.
- 利用聚合酶连锁反应 (PCR) 进行血型定型和病毒性决定因子检测.
- 采用多个位置变量数并列重复分析 (MLVA) 进行基因相关性和磁盘扩散,用于抗菌素敏感性测试.
主要成果:
- 血清型III和V是最常见的 (25%),其次是II,Ia,VI和Ib.
- 鉴定出一种高病毒性血清型III/CC17克隆.
- 对四环素 (76.47%),红色素 (36.76%) 和克林达胺素 (25.49%) 观察到高耐药率.
- 青素敏感性保持不变,而宏类耐药性表型则有所不同.
- MLVA揭示了遗传多样性,与特定MLVA类型相关的宏化物耐药性.
结论:
- 沙特成年人的GBS主要是III和V血清型.
- 没有发现明确的血清型-患者组关联.
- 高红素和克林达米辛耐药水平需要进一步监测.
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