系统性审查和元分析以估计成年人群中循环电离度的参考范围
Velarie Y Ansu Baidoo1, Kelly C Cara2, Stephanie L Dickinson3
1Northwestern University Feinberg School of Medicine, Chicago, IL, United States.
The Journal of nutrition
|October 16, 2023
概括
确定电离 (iMg2+) 和总 (Mg) 的参考范围对于诊断心脏代谢疾病至关重要. 这项研究为健康成年人和患有心血管疾病,糖尿病,高血压和病等疾病的人提供了估计范围.
科学领域:
- 临床化学 临床化学
- 生物标志物 生物标志物
- 心血管健康 心血管健康
背景情况:
- 关于血液中电离 (iMg2+) 的参考范围缺乏共识.
- 准确的IMg2+范围是必要的,以对人口进行查和评估的状态.
研究的目的:
- 在健康成年人和患有心血管疾病 (CVD),2型糖尿病,高血压和病的个人中估计iMg2+的参考范围.
- 确定健康成年人和患有心脏代谢疾病的人群中总循环 (Mg) 的参考范围.
主要方法:
- 在2020年7月之前对奥维德·梅德林,科克伦和埃姆巴斯的系统文献搜索.
- 包括在基线测量Img2+或Mg的同行评审研究.
- 使用频率主义随机效应模型计算聚合平均值和95%置信区间的元分析.
主要成果:
- 包括95篇文章 (53篇是健康的,42篇是心脏代谢疾病).
- 据估计,健康人群的Img2+参考范围为:0.40-0.68 mmol/L.
- 估计的总Mg范围在各种条件之间有所不同,健康状态和疾病状态之间有显著的重叠.
结论:
- 在心脏代谢疾病中,IMg2+和总Mg的估计参考范围很广,与健康范围重叠.
- 需要进一步的研究来验证iMg2+作为心脏代谢疾病的潜在生物标志物.
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