由持久性有机污染物和营养干预引起的炎症和心脏代谢疾病:多器官相互作用的影响
Zhongmin Wang1, Yixuan Zhou2, Xia Xiao2
1Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, China; Irish Centre for Vascular Biology, School of Pharmacy & Biomolecular Sciences, Royal College of Surgeons in Ireland, Ireland.
Environmental pollution (Barking, Essex : 1987)
|October 16, 2023
概括
像PCB和PFAS这样的持久有机污染物 (POP) 驱动炎症和心脏代谢疾病. 营养策略和系统生物学为管理这些环境引起的健康问题提供了新的方法.
科学领域:
- 环境健康科学 环境健康科学
- 毒理学 毒理学 毒理学
- 营养科学 营养科学
- 系统生物学 系统生物学
背景情况:
- 炎症性疾病受到遗传和生活方式因素的影响,包括化学压力因素,如持久性有机污染物 (POP).
- 特定的POP如二氧化类多二 (PCB),和多基物质 (PFAS) 和多二乙烯 (PBDE) 与炎症性疾病有关.
- 环境化学物质的暴露可以引发影响多个器官的复杂病理,包括肠道,肝脏,大脑,血管系统和免疫系统.
研究的目的:
- 审查环境污染物诱导炎症和心脏代谢疾病的机制.
- 在污染物引起的疾病的背景下,专注于多个器官之间的相互作用.
- 突出最近在营养策略中取得的进展,以减轻环境暴露造成的不良健康结果.
- 讨论系统生物学在理解复杂相互作用和开发精确干预方面的作用.
主要方法:
- 对环境污染物诱导的炎症和心脏代谢疾病的现有科学文献的审查.
- 在疾病病理学中分析多器官相互作用.
- 评估营养策略及其对疾病调节的影响.
- 讨论复杂相互作用分析的系统生物学方法.
主要成果:
- 包括POP在内的环境污染物是导致炎症和心脏代谢疾病的重要因素.
- 饮食营养素可以调节环境侮辱对疾病发展和进展的影响.
- 多器官相互作用在环境诱导疾病的病理学中至关重要.
结论:
- 了解污染物诱导的炎症和心脏代谢疾病的机制至关重要.
- 营养干预措施有望改善暴露在环境污染物的个体的结果.
- 先进的系统生物学方法对于揭示复杂的相互作用和实现个性化治疗策略至关重要.
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