临床疾病活动指数在狼关节病的适用性:解开未被确诊的关节活动
Carlos Antonio Moura1,2, Vanessa Fonseca2, Eneida M Alves2
1Department of Internal Medicine, Sister Dulce's Social Works, Santo Antonio's Hospital, Salvador, Brazil.
Lupus
|October 16, 2023
概括
临床疾病活动指数 (CDAI) 比SLEDAI-2K更好地识别狼性关节炎活动和Jaccoud型关节病. CDAI检测到更多的狼性关节炎病例,突出显示了狼患者的敏感性.
科学领域:
- 类风湿病学 类风湿病学
- 系统性自身免疫性疾病
背景情况:
- 狼关节病 (LA) 涵盖了一系列关节干扰,从轻微的疼痛到严重的形.
- 目前用于测量狼性关节炎活动的复合得分可能缺乏灵敏度和实用性.
- 对LA的不断变化的理解需要改进的评估工具.
研究的目的:
- 为了评估系统性红斑狼 (SLE) 患者的关节模式.
- 为了比较临床疾病活动指数 (CDAI) 与2000年系统性狼红斑血性疾病活动指数 (SLEDAI-2K) 在评估狼关节炎中的有效性.
- 为了确定CDAI,SLEDAI-2K联合标准和Jaccoud型关节病 (JA) 之间的关联.
主要方法:
- 一项涉及127名SLE患者的横截面研究.
- 用CDAI和SLEDAI-2K来评估患者的关节活动.
- 进行了统计分析,以将CDAI和SLEDAI-2K得分与JA的存在相关联.
主要成果:
- CDAI在25.19%的患者中发现了关节活动,而SLEDAI-2K在13.4%的患者中发现了关节活动.
- 一半的CDAI检测到活性的患者不符合SLEDAI-2K联合标准.
- 雅库德型关节病与CDAI (p=.014) 有显著的关联,但与SLEDAI-2K (p=.524) 没有显著的关联.
结论:
- 与SLEDAI-2K联合标准相比,CDAI在检测狼性关节炎方面似乎更敏感.
- 根据CDAI测量,Jaccoud型关节病与疾病活动有显著的相关性.
- CDAI可以提供一个更实用和敏感的工具来评估SLE的联合参与.
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