一步一步:融合驱动的皮肤瘤中的黑色细胞分化
1Department of Pathology & Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Journal of cutaneous pathology
|October 16, 2023
概括
黑色素瘤的诊断是复杂的,因为具有黑色素细胞特征的瘤可以来自各种来源. 最近的分子发现,如MITF通路激活和EWSR1::CREM融合,正在改进瘤分类.
科学领域:
- 在瘤学瘤学.
- 皮肤病理学 皮肤病理学
- 分子诊断学 分子诊断
背景情况:
- 瘤中的黑色素细胞分化并不总是表明黑色素瘤,瘤或黑色素细胞瘤.
- 不同的瘤,包括透明细胞肉瘤和PEComa,合成黑色素.
- 在过去的二十年中,分子诊断显著提高了对瘤分类的理解.
研究的目的:
- 为了突出最近的进展,分类瘤与黑色素细胞分化.
- 讨论将新型分子发现纳入瘤分类的整合.
- 强调分子诊断在区分具有相似组织学特征的瘤方面的重要性.
主要方法:
- 关于黑色细胞瘤的最新文献和病例报告的审查.
- 分析分子诊断数据,包括基因融合和通路激活.
- 讨论最新的世卫组织皮肤瘤分类.
主要成果:
- 识别新的瘤实体和遗传变异,如CRTC1::TRIM11和MITF通路激活的黑色素细胞瘤 (ACTIN::MITF,MITF::CREM).
- 病例报告说明了诊断方面的挑战,包括被误诊为黑色素瘤的EWSR1::CREM融合透明细胞肉瘤.
- 将新的分子发现纳入世卫组织皮肤瘤分类第五版.
结论:
- 由于分子发现,黑色细胞瘤的景观正在迅速发展.
- 准确的诊断需要将组织病理学与先进的分子技术相结合.
- 持续的研究对于理解和分类这些复杂的瘤至关重要.
相关概念视频
01:30Skin Cancer
4.2K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
4.2K
01:19Pigmentation
2.5K
The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
2.5K