基抗菌剂用于对抗耐药性病原体
Olajide Sunday Faleye1, Bharath Reddy Boya1, Jin-Hyung Lee1
1School of Chemical Engineering (O.S.F., B.R.B., J.-H.L., J.L.) and Department of Medical Biotechnology (I.C.), Yeungnam University, Gyeongsan, Republic of Korea.
Pharmacological reviews
|October 16, 2023
概括
抗生素中的原子对于对抗微生物和克服抗菌素耐药性至关重要. 本综述探讨了化如何增强药物特性和对抗耐药病原体的活性.
科学领域:
- 药用化学 医学化学
- 药理学 药理学是指药理学的学科.
- 微生物学 微生物学
背景情况:
- 抗菌素耐药性 (AMR) 构成了全球健康的重大威胁,降低了传统抗生素的疗效.
- 从历史上看,原子在抗菌剂开发中发挥了作用.
- 了解素对抗微生物特性的影响对于开发新的治疗策略至关重要.
研究的目的:
- 综合审查原子在抗生素支架中的作用及其对抗菌活性的影响.
- 探索结构-活性关系和受化影响的作用机制.
- 评估化在克服抗菌素耐药性和复原现有抗生素方面的潜力.
主要方法:
- 对基抗菌剂现有研究的文献综述.
- 分析各种含有素的抗微生物支架 (例如碳水化合物,,脂质).
- 评估化对药理动力学,药理动力学和抗病毒活性的影响.
主要成果:
- 原子显著影响抗微生物活性,耐药性概况和药理动力学/药理动力学特性.
- 化可以增强现有抗生素的疗效,并可能规避耐药机制.
- 包括复杂结构在内的各种素分子显示出治疗潜力.
结论:
- 化是提高抗微生物药物的有效性和打击耐药性的关键策略.
- 对基支架的进一步研究为开发新疗法提供了有希望的途径,以防止后抗生素时代.
- 本综述强调了素在抗菌药物设计和开发中的既定和新兴作用.
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